How to Get Rid of Nasal Polyps without Surgery ?

Dr. Claus Bachert of Ghent University, in Belgium and colleagues assessed the efficacy and safety of dupilumab when added to intranasal corticosteroids in adults with severe Nasal Polyps in two phase-3 trials, LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52.


In SINUS-24, researchers assigned 143 patients to dupilumab every two weeks and 133 patients to placebo; in SINUS-52, 150 patients received dupilumab every two weeks, 145 every two weeks until week 24 and every four weeks until week 52, and 153 patients received placebo.

At baseline, mean bilateral endoscopic nasal polyp score (NPS) was 5.97 (scale, 0-8) and mean nasal congestion or obstruction score was 2.40 (scale, 0-3) in the overall population. Changes in these measures were the co-primary endpoints in both studies.

Endoscopic NPS decreased by a mean 1.89 points in SINUS-24 and by a mean 1.71 points in SINUS-52 with dupilumab every two weeks, compared with slight increases with placebo (0.17 and 0.10 point, respectively), the team reports in The Lancet, online September 19.

Nasal congestion or obstruction scores also improved significantly in both studies (by a mean 1.34 and 1.25 points, respectively), compared with placebo (mean improvements of 0.45 and 0.38 points, respectively).

 These data support the benefits of adding dupilumab to daily standard of care in patients with Nasal Polyps as a novel approach in treating the entire spectrum of clinical manifestations of the disease, a predominantly type 2 inflammatory condition, as well as the frequently associated type 2 lower airway comorbidities," the authors conclude.

Clearly, patients with Nasal Polyps who have failed sinus surgery, have contraindications to surgery, and/or who have required frequent systemic corticosteroids to manage their disease would be candidates for dupilumab,. Additionally, patients with both asthma and Nasal Polyps  are appropriate candidates. 

Read more :  How to Cure Nasal Polyps Permanently and Naturally at Home ?

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